Sample Set Annotation Tool: Genome-wide profiling of whole blood from patients with defects in Toll-like receptors (TLRs) and IL-1Rs (the TIR pathway) signaling. GSE25742

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

The objective of this study is to: 1) Characterize the innate immune responsiveness of patients with inborn errors in Toll-IL1 receptor signaling pathway (IRAK4, MyD88 deficiencies) compared to healthy subjects, through the analysis of blood leukocytes' transcriptional profiles after stimulation with ligands for the whole set of Toll-like receptors and IL-1Rs plus whole bacteria. 2) Understand the redundancies in TLR pathway in humans. 3) Explore the use of blood profiling approaches to assess the immune status of an individual by using Primary Immune Deficiencies as a proof of principle.

Hypothesis

Experimental Design

A total of 22 blood samples were collected from three groups of subjects: 4 patients with complete MYD88 deficiency, 4 patients with complete IRAK4 deficiency, and 14 healthy donors. Mutations from IRAK4 and MYD88 patients are loss-of-function. The subjects were recruited in two different batches: first set includes 4 healthy controls, MYD88 P1 and P2, IRAK4 P1 and P2 patients. Second set includes 10 different healthy controls, MYD88 P3 and P4 and IRAK4 P3 and P4. Healthy individuals are considered so based on past medical history (no recurrent infections). They were also healthy at the time of sampling. From each subject, peripheral blood was drawn into sodium heparin vacuum tubes on clinic site (Necker Hospital, Paris). Right away, 500µl whole blood was diluted with the same amount of RPMI before adding different stimulus. Diluted whole blood was activated with a wide range of ligands (16 conditions total, see below) in a volume of 50 µl, for 2 hours along with 10µg/ml of polymyxin B to clear LPS contamination in reagents. Whole blood was lysated with Tempus solution (from Tempus tubes, Applied Biosystems) to stabilize the RNA at 1:3 ratio after restimulation. The lysates were kept at -80ºC temperature until mRNA extraction. A total of 365 samples were analyzed. Choice of agonists: PAM3 (TLR1/2) and PAM2 (TLR2/6), 100 ng/ml final concentration, Invivogen®; poly(I:C) 25 µg/ml final concentration, Invivogen® (TLR3); LPS 100 ng/ml final concentration, Sigma® (TLR4); Flagellin 100 ng/ml final concentration, Invivogen® (TLR5); 3M13 (TLR7) and 3M2 (TLR8), 3µg/ml final concentration, 3M pharmaceuticals®; R848 3µg/ml final concentration, Invivogen® (TLR7/8); CpG-D19 and CPG C (TLR9), 3µg/ml final concentration, from collaborator. Agonists for IL-1R: IL-1b 20ng/ml final concentration, IL18 and IL33 50ng/ml final concentration, from RaD systems®; agonist for TNFa receptor, TNFa, 20ng/ml final concentration, from RaD systems®; PMA 25 ng/ml + Ionomycin 1µg/ml final concentration, Sigma®; heat killed whole bacteria: 3 pneumococcal strains (R6, 5.106 partical/ml final concentration; R8450 108 partical/ml final concentration; R11470, 5.106 partical/ml final concentration, heat killed at 65°C for 15 min) from collaborator, and Staphylococcus aureus (SAC), 107 partical/ml final concentration, from Invivogen®. No stimulation serves as negative control and PMA/ionomycin stimulation as positive cont

Experimental Variables

Controls

Methods

Additional Information

Expected Samples:

365 Samples Loaded: 365

Species

Human (Homo sapiens)

Sample Source

Whole Blood

Disease

IRAK-4 deficiency, MyD88 deficiency

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	!Sample Title	Gender	Illness	group	geographic
GSM632242	control 6_poly(I:C)	M	healthy control	Control poly IC	France
GSM632243	control 3__3M2	F	healthy control	Control 3M2	France
GSM632244	IRAK4 P4_SAC	F	IRAK4-/- patient	AR IRAK4 SAC	UK
GSM632245	control 4__3M2	M	healthy control	Control 3M2	France
GSM632246	control 3_IL-1b	F	healthy control	Control IL1b	France

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File
sampleset4000031_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000031_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000031_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000031_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000031_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000031_sampleannotations_Group.csv Sample Set Spreadsheet

Samples Viewer / Editor

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Sample ID	!Sample Title	Gender	Illness	Group	Geographic	Race	Age at enrollment	Cell population	In vitro stimulation blood volume per condition	In vitro stimulation condition	In vitro stimulation incubation time
GSM632242	control 6_poly(I:C)	M	healthy control	Control poly IC	France	White	30	Whole blood	1 ml	poly(I:C)	2h
GSM632243	control 3__3M2	F	healthy control	Control 3M2	France	White	42	Whole blood	1 ml	3M2	2h
GSM632244	IRAK4 P4_SAC	F	IRAK4-/- patient	AR IRAK4 SAC	UK	White	14	Whole blood	1 ml	SAC	2h
GSM632245	control 4__3M2	M	healthy control	Control 3M2	France	White	35	Whole blood	1 ml	3M2	2h
GSM632246	control 3_IL-1b	F	healthy control	Control IL1b	France	White	42	Whole blood	1 ml	IL-1b	2h
GSM632247	control 4_No stimulation	M	healthy control	Control No stimulation	France	White	35	Whole blood	1 ml	No stimulation	2h
GSM632248	IRAK4 P4_PAM3	F	IRAK4-/- patient	AR IRAK4 PAM3	UK	White	14	Whole blood	1 ml	PAM3	2h
GSM632249	IRAK4 P3_LPS	M	IRAK4-/- patient	AR IRAK4 LPS	Portugal	White	14	Whole blood	1 ml	LPS	2h
GSM632250	control 5_PAM3	F	healthy control	Control PAM3	France	White	45	Whole blood	1 ml	PAM3	2h
GSM632251	control 2_poly(I:C)	F	healthy control	Control poly IC	France	White	40	Whole blood	1 ml	poly(I:C)	2h
GSM632252	IRAK4 P4_R848	F	IRAK4-/- patient	AR IRAK4 R848	UK	White	14	Whole blood	1 ml	R848	2h
GSM632253	IRAK4 P3_IL18	M	IRAK4-/- patient	AR IRAK4 IL18	Portugal	White	14	Whole blood	1 ml	IL18	2h
GSM632254	IRAK4 P4_IL33	F	IRAK4-/- patient	AR IRAK4 IL33	UK	White	14	Whole blood	1 ml	IL33	2h
GSM632255	control 6_R8450	M	healthy control	Control R8450	France	White	30	Whole blood	1 ml	R8450	2h
GSM632256	control 6_Flagellin	M	healthy control	Control Flagellin	France	White	30	Whole blood	1 ml	Flagellin	2h
GSM632257	control 6_PMA/Iono	M	healthy control	Control PMA Iono	France	White	30	Whole blood	1 ml	PMA/Iono	2h
GSM632258	IRAK4 P4_PMA/Iono	F	IRAK4-/- patient	AR IRAK4 PMA Iono	UK	White	14	Whole blood	1 ml	PMA/Iono	2h
GSM632259	IRAK4 P4_TNFa	F	IRAK4-/- patient	AR IRAK4 TNFa	UK	White	14	Whole blood	1 ml	TNFa	2h
GSM632260	control 4_R6	M	healthy control	Control R6	France	White	35	Whole blood	1 ml	R6	2h
GSM632261	control 6_3M13	M	healthy control	Control 3M13	France	White	30	Whole blood	1 ml	3M13	2h
GSM632262	control 4_R11470	M	healthy control	Control R11470	France	White	35	Whole blood	1 ml	R11470	2h
GSM632263	IRAK4 P3_SAC	M	IRAK4-/- patient	AR IRAK4 SAC	Portugal	White	14	Whole blood	1 ml	SAC	2h
GSM632264	IRAK4 P3_CpG-D19	M	IRAK4-/- patient	AR IRAK4 CpG D19	Portugal	White	14	Whole blood	1 ml	CpG-D19	2h
GSM632265	IRAK4 P4_R11470	F	IRAK4-/- patient	AR IRAK4 R11470	UK	White	14	Whole blood	1 ml	R11470	2h
GSM632266	IRAK4 P3_TNFa	M	IRAK4-/- patient	AR IRAK4 TNFa	Portugal	White	14	Whole blood	1 ml	TNFa	2h
GSM632267	IRAK4 P3_PAM3	M	IRAK4-/- patient	AR IRAK4 PAM3	Portugal	White	14	Whole blood	1 ml	PAM3	2h
GSM632268	IRAK4 P4_CpG-D19	F	IRAK4-/- patient	AR IRAK4 CpG D19	UK	White	14	Whole blood	1 ml	CpG-D19	2h
GSM632269	control 1_poly(I:C)	M	healthy control	Control poly IC	Portugal	White	38	Whole blood	1 ml	poly(I:C)	2h
GSM632270	IRAK4 P3_CpG C	M	IRAK4-/- patient	AR IRAK4 CpG C	Portugal	White	14	Whole blood	1 ml	CpG C	2h
GSM632271	control 2_CpG C	F	healthy control	Control CpG C	France	White	40	Whole blood	1 ml	CpG C	2h
GSM632272	IRAK4 P3_PAM2	M	IRAK4-/- patient	AR IRAK4 PAM2	Portugal	White	14	Whole blood	1 ml	PAM2	2h
GSM632273	control 3_No stimulation	F	healthy control	Control No stimulation	France	White	42	Whole blood	1 ml	No stimulation	2h
GSM632274	IRAK4 P4__3M2	F	IRAK4-/- patient	AR IRAK4 3M2	UK	White	14	Whole blood	1 ml	3M2	2h
GSM632275	control 6_CpG C	M	healthy control	Control CpG C	France	White	30	Whole blood	1 ml	CpG C	2h
GSM632276	control 3_Flagellin	F	healthy control	Control Flagellin	France	White	42	Whole blood	1 ml	Flagellin	2h
GSM632277	control 3_IL33	F	healthy control	Control IL33	France	White	42	Whole blood	1 ml	IL33	2h
GSM632278	IRAK4 P3_IL33	M	IRAK4-/- patient	AR IRAK4 IL33	Portugal	White	14	Whole blood	1 ml	IL33	2h
GSM632279	IRAK4 P4_Flagellin	F	IRAK4-/- patient	AR IRAK4 Flagellin	UK	White	14	Whole blood	1 ml	Flagellin	2h
GSM632280	control 4_PMA/Iono	M	healthy control	Control PMA Iono	France	White	35	Whole blood	1 ml	PMA/Iono	2h
GSM632281	control 2_CpG-D19	F	healthy control	Control CpG D19	France	White	40	Whole blood	1 ml	CpG-D19	2h
GSM632282	IRAK4 P4_R6	F	IRAK4-/- patient	AR IRAK4 R6	UK	White	14	Whole blood	1 ml	R6	2h
GSM632283	IRAK4 P4_IL-1b	F	IRAK4-/- patient	AR IRAK4 IL1b	UK	White	14	Whole blood	1 ml	IL-1b	2h
GSM632284	control 3_poly(I:C)	F	healthy control	Control poly IC	France	White	42	Whole blood	1 ml	poly(I:C)	2h
GSM632285	control 1_CpG C	M	healthy control	Control CpG C	Portugal	White	38	Whole blood	1 ml	CpG C	2h
GSM632286	control 2_3M13	F	healthy control	Control 3M13	France	White	40	Whole blood	1 ml	3M13	2h
GSM632287	control 4_CpG-D19	M	healthy control	Control CpG D19	France	White	35	Whole blood	1 ml	CpG-D19	2h
GSM632288	IRAK4 P3_R848	M	IRAK4-/- patient	AR IRAK4 R848	Portugal	White	14	Whole blood	1 ml	R848	2h
GSM632289	control 3_PAM3	F	healthy control	Control PAM3	France	White	42	Whole blood	1 ml	PAM3	2h
GSM632290	control 4_IL-1b	M	healthy control	Control IL1b	France	White	35	Whole blood	1 ml	IL-1b	2h
GSM632291	control 6_TNFa	M	healthy control	Control TNFa	France	White	30	Whole blood	1 ml	TNFa	2h
GSM632292	IRAK4 P4_poly(I:C)	F	IRAK4-/- patient	AR IRAK4 poly IC	UK	White	14	Whole blood	1 ml	poly(I:C)	2h
GSM632293	control 4_R8450	M	healthy control	Control R8450	France	White	35	Whole blood	1 ml	R8450	2h
GSM632294	control 6_LPS	M	healthy control	Control LPS	France	White	30	Whole blood	1 ml	LPS	2h
GSM632295	IRAK4 P3_R6	M	IRAK4-/- patient	AR IRAK4 R6	Portugal	White	14	Whole blood	1 ml	R6	2h
GSM632296	control 5_IL33	F	healthy control	Control IL33	France	White	45	Whole blood	1 ml	IL33	2h
GSM632297	control 2_No stimulation	F	healthy control	Control No stimulation	France	White	40	Whole blood	1 ml	No stimulation	2h
GSM632298	IRAK4 P3_IL-1b	M	IRAK4-/- patient	AR IRAK4 IL1b	Portugal	White	14	Whole blood	1 ml	IL-1b	2h
GSM632299	control 6__3M2	M	healthy control	Control 3M2	France	White	30	Whole blood	1 ml	3M2	2h
GSM632300	control 5_No stimulation	F	healthy control	Control No stimulation	France	White	45	Whole blood	1 ml	No stimulation	2h
GSM632301	control 1_CpG-D19	M	healthy control	Control CpG D19	Portugal	White	38	Whole blood	1 ml	CpG-D19	2h
GSM632302	IRAK4 P4_R8450	F	IRAK4-/- patient	AR IRAK4 R8450	UK	White	14	Whole blood	1 ml	R8450	2h
GSM632303	control 1_No stimulation	M	healthy control	Control No stimulation	Portugal	White	38	Whole blood	1 ml	No stimulation	2h
GSM632304	control 6_No stimulation	M	healthy control	Control No stimulation	France	White	30	Whole blood	1 ml	No stimulation	2h
GSM632305	control 5_TNFa	F	healthy control	Control TNFa	France	White	45	Whole blood	1 ml	TNFa	2h
GSM632306	control 3_PMA/Iono	F	healthy control	Control PMA Iono	France	White	42	Whole blood	1 ml	PMA/Iono	2h
GSM632307	control 5_LPS	F	healthy control	Control LPS	France	White	45	Whole blood	1 ml	LPS	2h
GSM632308	control 4_Flagellin	M	healthy control	Control Flagellin	France	White	35	Whole blood	1 ml	Flagellin	2h
GSM632309	control 2_PMA/Iono	F	healthy control	Control PMA Iono	France	White	40	Whole blood	1 ml	PMA/Iono	2h
GSM632310	control 6_R848	M	healthy control	Control R848	France	White	30	Whole blood	1 ml	R848	2h
GSM632311	control 5_PMA/Iono	F	healthy control	Control PMA Iono	France	White	45	Whole blood	1 ml	PMA/Iono	2h
GSM632312	control 2__3M2	F	healthy control	Control 3M2	France	White	40	Whole blood	1 ml	3M2	2h
GSM632313	control 2_LPS	F	healthy control	Control LPS	France	White	40	Whole blood	1 ml	LPS	2h
GSM632314	IRAK4 P4_3M13	F	IRAK4-/- patient	AR IRAK4 3M13	UK	White	14	Whole blood	1 ml	3M13	2h
GSM632315	control 6_IL-1b	M	healthy control	Control IL1b	France	White	30	Whole blood	1 ml	IL-1b	2h
GSM632316	control 2_Flagellin	F	healthy control	Control Flagellin	France	White	40	Whole blood	1 ml	Flagellin	2h
GSM632317	control 3_R848	F	healthy control	Control R848	France	White	42	Whole blood	1 ml	R848	2h
GSM632318	MYD88 P4_Flagellin	F	MYD88-/- patient	AR MyD88 Flagellin	Turkish	White	5	Whole blood	1 ml	Flagellin	2h
GSM632319	MYD88 P3_IL-1b	F	MYD88-/- patient	AR MyD88 IL1b	Traveller (Gypsies)	White	2	Whole blood	1 ml	IL-1b	2h
GSM632320	control 7_CpG-D19	M	healthy control	Control CpG D19	France	White	40	Whole blood	1 ml	CpG-D19	2h
GSM632321	control 9_R6	M	healthy control	Control R6	France	White	31	Whole blood	1 ml	R6	2h
GSM632322	MYD88 P3__3M2	F	MYD88-/- patient	AR MyD88 3M2	Traveller (Gypsies)	White	2	Whole blood	1 ml	3M2	2h
GSM632323	control 9_PAM3	M	healthy control	Control PAM3	France	White	31	Whole blood	1 ml	PAM3	2h
GSM632324	control 7_Flagellin	M	healthy control	Control Flagellin	France	White	40	Whole blood	1 ml	Flagellin	2h
GSM632325	control 7_R11470	M	healthy control	Control R11470	France	White	40	Whole blood	1 ml	R11470	2h
GSM632326	control 8_R6	F	healthy control	Control R6	France	White	42	Whole blood	1 ml	R6	2h
GSM632327	control 10_TNFa	M	healthy control	Control TNFa	Turkish	White	33	Whole blood	1 ml	TNFa	2h
GSM632328	MYD88 P4_TNFa	F	MYD88-/- patient	AR MyD88 TNFa	Turkish	White	5	Whole blood	1 ml	TNFa	2h
GSM632329	control 8_Flagellin	F	healthy control	Control Flagellin	France	White	42	Whole blood	1 ml	Flagellin	2h
GSM632330	control 10_PMA/Iono	M	healthy control	Control PMA Iono	Turkish	White	31	Whole blood	1 ml	PMA/Iono	2h
GSM632331	MYD88 P4_No stimulation	F	MYD88-/- patient	AR MyD88 No stimulation	Turkish	White	5	Whole blood	1 ml	No stimulation	2h
GSM632332	MYD88 P3_No stimulation	F	MYD88-/- patient	AR MyD88 No stimulation	Traveller (Gypsies)	White	2	Whole blood	1 ml	No stimulation	2h
GSM632333	MYD88 P3_SAC	F	MYD88-/- patient	AR MyD88 SAC	Traveller (Gypsies)	White	2	Whole blood	1 ml	SAC	2h
GSM632334	control 8_poly(I:C)	F	healthy control	Control poly IC	France	White	42	Whole blood	1 ml	poly(I:C)	2h
GSM632335	MYD88 P4_IL-1b	F	MYD88-/- patient	AR MyD88 IL1b	Turkish	White	5	Whole blood	1 ml	IL-1b	2h
GSM632336	control 7_R8450	M	healthy control	Control R8450	France	White	40	Whole blood	1 ml	R8450	2h
GSM632337	control 9_Flagellin	M	healthy control	Control Flagellin	France	White	31	Whole blood	1 ml	Flagellin	2h
GSM632338	MYD88 P3_TNFa	F	MYD88-/- patient	AR MyD88 TNFa	Traveller (Gypsies)	White	2	Whole blood	1 ml	TNFa	2h
GSM632339	MYD88 P4_SAC	F	MYD88-/- patient	AR MyD88 SAC	Turkish	White	5	Whole blood	1 ml	SAC	2h
GSM632340	MYD88 P4_CpG-D19	F	MYD88-/- patient	AR MyD88 CpG D19	Turkish	White	5	Whole blood	1 ml	CpG-D19	2h
GSM632341	control 7_No stimulation	M	healthy control	Control No stimulation	France	White	40	Whole blood	1 ml	No stimulation	2h
GSM632342	control 8_LPS	F	healthy control	Control LPS	France	White	42	Whole blood	1 ml	LPS	2h
GSM632343	control 7_PMA/Iono	M	healthy control	Control PMA Iono	France	White	40	Whole blood	1 ml	PMA/Iono	2h
GSM632344	MYD88 P3_PMA/Iono	F	MYD88-/- patient	AR MyD88 PMA Iono	Traveller (Gypsies)	White	2	Whole blood	1 ml	PMA/Iono	2h
GSM632345	control 8__3M2	F	healthy control	Control 3M2	France	White	42	Whole blood	1 ml	3M2	2h
GSM632346	MYD88 P3_R11470	F	MYD88-/- patient	AR MyD88 R11470	Traveller (Gypsies)	White	2	Whole blood	1 ml	R11470	2h
GSM632347	control 8_CpG C	F	healthy control	Control CpG C	France	White	42	Whole blood	1 ml	CpG C	2h
GSM632348	MYD88 P3_Flagellin	F	MYD88-/- patient	AR MyD88 Flagellin	Traveller (Gypsies)	White	2	Whole blood	1 ml	Flagellin	2h
GSM632349	control 10_R848	M	healthy control	Control R848	Turkish	White	33	Whole blood	1 ml	R848	2h
GSM632350	control 10_R6	M	healthy control	Control R6	Turkish	White	33	Whole blood	1 ml	R6	2h
GSM632351	MYD88 P4_CpG C	F	MYD88-/- patient	AR MyD88 CpG C	Turkish	White	5	Whole blood	1 ml	CpG C	2h
GSM632352	MYD88 P4_R11470	F	MYD88-/- patient	AR MyD88 R11470	Turkish	White	5	Whole blood	1 ml	R11470	2h
GSM632353	IRAK4 P3_R11470	M	IRAK4-/- patient	AR IRAK4 R11470	Portugal	White	14	Whole blood	1 ml	R11470	2h
GSM632354	IRAK4 P3_Flagellin	M	IRAK4-/- patient	AR IRAK4 Flagellin	Portugal	White	14	Whole blood	1 ml	Flagellin	2h
GSM632355	control 5_CpG-D19	F	healthy control	Control CpG D19	France	White	45	Whole blood	1 ml	CpG-D19	2h
GSM632356	control 4_PAM2	M	healthy control	Control PAM2	France	White	35	Whole blood	1 ml	PAM2	2h
GSM632357	control 6_SAC	M	healthy control	Control SAC	France	White	30	Whole blood	1 ml	SAC	2h
GSM632358	control 6_CpG-D19	M	healthy control	Control CpG D19	France	White	30	Whole blood	1 ml	CpG-D19	2h
GSM632359	control 5_poly(I:C)	F	healthy control	Control poly IC	France	White	45	Whole blood	1 ml	poly(I:C)	2h
GSM632360	control 1_R848	M	healthy control	Control R848	Portugal	White	38	Whole blood	1 ml	R848	2h
GSM632361	control 5__3M2	F	healthy control	Control 3M2	France	White	45	Whole blood	1 ml	3M2	2h
GSM632362	control 5_Flagellin	F	healthy control	Control Flagellin	France	White	45	Whole blood	1 ml	Flagellin	2h
GSM632363	control 4_poly(I:C)	M	healthy control	Control poly IC	France	White	35	Whole blood	1 ml	poly(I:C)	2h
GSM632364	control 5_IL18	F	healthy control	Control IL18	France	White	45	Whole blood	1 ml	IL18	2h
GSM632365	control 1__3M2	M	healthy control	Control 3M2	Portugal	White	38	Whole blood	1 ml	3M2	2h
GSM632366	IRAK4 P3_3M13	M	IRAK4-/- patient	AR IRAK4 3M13	Portugal	White	14	Whole blood	1 ml	3M13	2h
GSM632367	control 4_CpG C	M	healthy control	Control CpG C	France	White	35	Whole blood	1 ml	CpG C	2h
GSM632368	IRAK4 P3_No stimulation	M	IRAK4-/- patient	AR IRAK4 No stimulation	Portugal	White	14	Whole blood	1 ml	No stimulation	2h
GSM632369	control 6_R6	M	healthy control	Control R6	France	White	30	Whole blood	1 ml	R6	2h
GSM632370	IRAK4 P3_poly(I:C)	M	IRAK4-/- patient	AR IRAK4 poly IC	Portugal	White	14	Whole blood	1 ml	poly(I:C)	2h
GSM632371	control 5_CpG C	F	healthy control	Control CpG C	France	White	45	Whole blood	1 ml	CpG C	2h
GSM632372	IRAK4 P4_LPS	F	IRAK4-/- patient	AR IRAK4 LPS	UK	White	14	Whole blood	1 ml	LPS	2h
GSM632373	control 4_R848	M	healthy control	Control R848	France	White	35	Whole blood	1 ml	R848	2h
GSM632374	IRAK4 P4_IL18	F	IRAK4-/- patient	AR IRAK4 IL18	UK	White	14	Whole blood	1 ml	IL18	2h
GSM632375	control 5_3M13	F	healthy control	Control 3M13	France	White	45	Whole blood	1 ml	3M13	2h
GSM632376	control 1_PAM3	M	healthy control	Control PAM3	Portugal	White	38	Whole blood	1 ml	PAM3	2h
GSM632377	control 6_PAM3	M	healthy control	Control PAM3	France	White	30	Whole blood	1 ml	PAM3	2h
GSM632378	IRAK4 P4_No stimulation	F	IRAK4-/- patient	AR IRAK4 No stimulation	UK	White	14	Whole blood	1 ml	No stimulation	2h
GSM632379	control 4_SAC	M	healthy control	Control SAC	France	White	35	Whole blood	1 ml	SAC	2h
GSM632380	control 4_PAM3	M	healthy control	Control PAM3	France	White	35	Whole blood	1 ml	PAM3	2h
GSM632381	control 4_TNFa	M	healthy control	Control TNFa	France	White	35	Whole blood	1 ml	TNFa	2h
GSM632382	control 5_IL-1b	F	healthy control	Control IL1b	France	White	45	Whole blood	1 ml	IL-1b	2h
GSM632383	control 1_PAM2	M	healthy control	Control PAM2	Portugal	White	38	Whole blood	1 ml	PAM2	2h
GSM632384	control 6_R11470	M	healthy control	Control R11470	France	White	30	Whole blood	1 ml	R11470	2h
GSM632385	control 6_IL18	M	healthy control	Control IL18	France	White	30	Whole blood	1 ml	IL18	2h
GSM632386	control 5_PAM2	F	healthy control	Control PAM2	France	White	45	Whole blood	1 ml	PAM2	2h
GSM632387	control 3_TNFa	F	healthy control	Control TNFa	France	White	42	Whole blood	1 ml	TNFa	2h
GSM632388	control 3_3M13	F	healthy control	Control 3M13	France	White	42	Whole blood	1 ml	3M13	2h
GSM632389	control 2_R848	F	healthy control	Control R848	France	White	40	Whole blood	1 ml	R848	2h
GSM632390	control 4_3M13	M	healthy control	Control 3M13	France	White	35	Whole blood	1 ml	3M13	2h
GSM632391	control 5_R848	F	healthy control	Control R848	France	White	45	Whole blood	1 ml	R848	2h
GSM632392	control 3_CpG-D19	F	healthy control	Control CpG D19	France	White	42	Whole blood	1 ml	CpG-D19	2h
GSM632393	IRAK4 P3_R8450	M	IRAK4-/- patient	AR IRAK4 R8450	Portugal	White	14	Whole blood	1 ml	R8450	2h
GSM632394	control 4_LPS	M	healthy control	Control LPS	France	White	35	Whole blood	1 ml	LPS	2h
GSM632395	control 4_IL18	M	healthy control	Control IL18	France	White	35	Whole blood	1 ml	IL18	2h
GSM632396	IRAK4 P4_PAM2	F	IRAK4-/- patient	AR IRAK4 PAM2	UK	White	14	Whole blood	1 ml	PAM2	2h
GSM632397	control 6_IL33	M	healthy control	Control IL33	France	White	30	Whole blood	1 ml	IL33	2h
GSM632398	control 3_CpG C	F	healthy control	Control CpG C	France	White	42	Whole blood	1 ml	CpG C	2h
GSM632399	control 4_IL33	M	healthy control	Control IL33	France	White	35	Whole blood	1 ml	IL33	2h
GSM632400	control 9_PAM2	M	healthy control	Control PAM2	France	White	31	Whole blood	1 ml	PAM2	2h
GSM632401	control 7_poly(I:C)	M	healthy control	Control poly IC	France	White	40	Whole blood	1 ml	poly(I:C)	2h
GSM632402	control 7_SAC	M	healthy control	Control SAC	France	White	40	Whole blood	1 ml	SAC	2h
GSM632403	control 9_IL18	M	healthy control	Control IL18	France	White	31	Whole blood	1 ml	IL18	2h
GSM632404	control 9_TNFa	M	healthy control	Control TNFa	France	White	31	Whole blood	1 ml	TNFa	2h
GSM632405	control 9_R848	M	healthy control	Control R848	France	White	31	Whole blood	1 ml	R848	2h
GSM632406	MYD88 P3_poly(I:C)	F	MYD88-/- patient	AR MyD88 poly IC	Traveller (Gypsies)	White	2	Whole blood	1 ml	poly(I:C)	2h
GSM632407	control 8_R848	F	healthy control	Control R848	France	White	42	Whole blood	1 ml	R848	2h
GSM632408	control 8_PAM3	F	healthy control	Control PAM3	France	White	42	Whole blood	1 ml	PAM3	2h
GSM632409	control 10_poly(I:C)	M	healthy control	Control poly IC	Turkish	White	33	Whole blood	1 ml	poly(I:C)	2h
GSM632410	control 7_R848	M	healthy control	Control R848	France	White	40	Whole blood	1 ml	R848	2h
GSM632411	MYD88 P4_IL33	F	MYD88-/- patient	AR MyD88 IL33	Turkish	White	5	Whole blood	1 ml	IL33	2h
GSM632412	control 9_IL33	M	healthy control	Control IL33	France	White	31	Whole blood	1 ml	IL33	2h
GSM632413	MYD88 P4_3M13	F	MYD88-/- patient	AR MyD88 3M13	Turkish	White	5	Whole blood	1 ml	3M13	2h
GSM632414	control 8_IL-1b	F	healthy control	Control IL1b	France	White	42	Whole blood	1 ml	IL-1b	2h
GSM632415	control 10_PAM3	M	healthy control	Control PAM3	Turkish	White	33	Whole blood	1 ml	PAM3	2h
GSM632416	control 10_3M13	M	healthy control	Control 3M13	Turkish	White	33	Whole blood	1 ml	3M13	2h
GSM632417	MYD88 P3_3M13	F	MYD88-/- patient	AR MyD88 3M13	Traveller (Gypsies)	White	2	Whole blood	1 ml	3M13	2h
GSM632418	control 7_CpG C	M	healthy control	Control CpG C	France	White	40	Whole blood	1 ml	CpG C	2h
GSM632419	control 8_No stimulation	F	healthy control	Control No stimulation	France	White	42	Whole blood	1 ml	No stimulation	2h
GSM632420	MYD88 P4_IL18	F	MYD88-/- patient	AR MyD88 IL18	Turkish	White	5	Whole blood	1 ml	IL18	2h
GSM632421	control 10_CpG C	M	healthy control	Control CpG C	Turkish	White	33	Whole blood	1 ml	CpG C	2h
GSM632422	MYD88 P3_R8450	F	MYD88-/- patient	AR MyD88 R8450	Traveller (Gypsies)	White	2	Whole blood	1 ml	R8450	2h
GSM632423	control 10_CpG-D19	M	healthy control	Control CpG D19	Turkish	White	33	Whole blood	1 ml	CpG-D19	2h
GSM632424	control 9_CpG C	M	healthy control	Control CpG C	France	White	31	Whole blood	1 ml	CpG C	2h
GSM632425	MYD88 P4_R848	F	MYD88-/- patient	AR MyD88 R848	Turkish	White	5	Whole blood	1 ml	R848	2h
GSM632426	control 7_IL33	M	healthy control	Control IL33	France	White	40	Whole blood	1 ml	IL33	2h
GSM632427	MYD88 P4_LPS	F	MYD88-/- patient	AR MyD88 LPS	Turkish	White	5	Whole blood	1 ml	LPS	2h
GSM632428	control 9_3M13	M	healthy control	Control 3M13	France	White	31	Whole blood	1 ml	3M13	2h
GSM632429	control 10_SAC	M	healthy control	Control SAC	France	White	31	Whole blood	1 ml	SAC	2h
GSM632430	control 7_IL-1b	M	healthy control	Control IL1b	France	White	40	Whole blood	1 ml	IL-1b	2h
GSM632431	control 10_R11470	M	healthy control	Control R11470	Turkish	White	33	Whole blood	1 ml	R11470	2h
GSM632432	control 9_R8450	M	healthy control	Control R8450	France	White	31	Whole blood	1 ml	R8450	2h
GSM632433	control 8_CpG-D19	F	healthy control	Control CpG D19	France	White	42	Whole blood	1 ml	CpG-D19	2h
GSM632434	control 8_SAC	F	healthy control	Control SAC	France	White	42	Whole blood	1 ml	SAC	2h
GSM632435	control 7_LPS	M	healthy control	Control LPS	France	White	40	Whole blood	1 ml	LPS	2h
GSM632436	MYD88 P3_CpG-D19	F	MYD88-/- patient	AR MyD88 CpG D19	Traveller (Gypsies)	White	2	Whole blood	1 ml	CpG-D19	2h
GSM632437	control 9_IL-1b	M	healthy control	Control IL1b	France	White	31	Whole blood	1 ml	IL-1b	2h
GSM632438	control 9_poly(I:C)	M	healthy control	Control poly IC	France	White	31	Whole blood	1 ml	poly(I:C)	2h
GSM632439	control 9__3M2	M	healthy control	Control 3M2	France	White	31	Whole blood	1 ml	3M2	2h
GSM632440	control 8_R8450	F	healthy control	Control R8450	France	White	42	Whole blood	1 ml	R8450	2h
GSM632441	control 10_LPS	M	healthy control	Control LPS	Turkish	White	33	Whole blood	1 ml	LPS	2h
GSM632442	MYD88 P3_PAM2	F	MYD88-/- patient	AR MyD88 PAM2	Traveller (Gypsies)	White	2	Whole blood	1 ml	PAM2	2h
GSM632443	MYD88 P4_poly(I:C)	F	MYD88-/- patient	AR MyD88 poly IC	Turkish	White	5	Whole blood	1 ml	poly(I:C)	2h
GSM632444	control 10_IL33	M	healthy control	Control IL33	Turkish	White	33	Whole blood	1 ml	IL33	2h
GSM632445	control 9_LPS	M	healthy control	Control LPS	France	White	31	Whole blood	1 ml	LPS	2h
GSM632446	control 8_IL18	F	healthy control	Control IL18	France	White	42	Whole blood	1 ml	IL18	2h
GSM632447	MYD88 P4_PAM3	F	MYD88-/- patient	AR MyD88 PAM3	Turkish	White	5	Whole blood	1 ml	PAM3	2h
GSM632448	control 9_No stimulation	M	healthy control	Control No stimulation	France	White	31	Whole blood	1 ml	No stimulation	2h
GSM632449	control 9_SAC	M	healthy control	Control SAC	France	White	33	Whole blood	1 ml	SAC	2h
GSM632450	MYD88 P3_PAM3	F	MYD88-/- patient	AR MyD88 PAM3	Traveller (Gypsies)	White	2	Whole blood	1 ml	PAM3	2h
GSM632451	control 8_PAM2	F	healthy control	Control PAM2	France	White	42	Whole blood	1 ml	PAM2	2h
GSM632452	MYD88 P3_R6	F	MYD88-/- patient	AR MyD88 R6	Traveller (Gypsies)	White	2	Whole blood	1 ml	R6	2h
GSM632453	control 8_R11470	F	healthy control	Control R11470	France	White	42	Whole blood	1 ml	R11470	2h
GSM632454	control 10_Flagellin	M	healthy control	Control Flagellin	Turkish	White	33	Whole blood	1 ml	Flagellin	2h
GSM632455	control 10_No stimulation	M	healthy control	Control No stimulation	Turkish	White	33	Whole blood	1 ml	No stimulation	2h
GSM632456	MYD88 P4_PAM2	F	MYD88-/- patient	AR MyD88 PAM2	Turkish	White	5	Whole blood	1 ml	PAM2	2h
GSM632457	MYD88 P3_R848	F	MYD88-/- patient	AR MyD88 R848	Traveller (Gypsies)	White	2	Whole blood	1 ml	R848	2h
GSM632458	control 7_IL18	M	healthy control	Control IL18	France	White	40	Whole blood	1 ml	IL18	2h
GSM632459	control 10_IL18	M	healthy control	Control IL18	Turkish	White	33	Whole blood	1 ml	IL18	2h
GSM632460	MYD88 P4_R8450	F	MYD88-/- patient	AR MyD88 R8450	Turkish	White	5	Whole blood	1 ml	R8450	2h
GSM632461	control 7_PAM3	M	healthy control	Control PAM3	France	White	40	Whole blood	1 ml	PAM3	2h
GSM632462	MYD88 P3_IL33	F	MYD88-/- patient	AR MyD88 IL33	Traveller (Gypsies)	White	2	Whole blood	1 ml	IL33	2h
GSM632463	control 8_TNFa	F	healthy control	Control TNFa	France	White	42	Whole blood	1 ml	TNFa	2h
GSM632464	control 10_PAM2	M	healthy control	Control PAM2	Turkish	White	33	Whole blood	1 ml	PAM2	2h
GSM632465	control 7_3M13	M	healthy control	Control 3M13	France	White	40	Whole blood	1 ml	3M13	2h
GSM632466	control 8_3M13	F	healthy control	Control 3M13	France	White	42	Whole blood	1 ml	3M13	2h
GSM632467	MYD88 P3_LPS	F	MYD88-/- patient	AR MyD88 LPS	Traveller (Gypsies)	White	2	Whole blood	1 ml	LPS	2h
GSM632468	control 8_IL33	F	healthy control	Control IL33	France	White	42	Whole blood	1 ml	IL33	2h
GSM632469	control 10_IL-1b	M	healthy control	Control IL1b	Turkish	White	33	Whole blood	1 ml	IL-1b	2h
GSM632470	control 7_PAM2	M	healthy control	Control PAM2	France	White	40	Whole blood	1 ml	PAM2	2h
GSM632471	control 8_PMA/Iono	F	healthy control	Control PMA Iono	France	White	42	Whole blood	1 ml	PMA/Iono	2h
GSM632472	control 10_R8450	M	healthy control	Control R8450	Turkish	White	33	Whole blood	1 ml	R8450	2h
GSM632473	control 10__3M2	M	healthy control	Control 3M2	Turkish	White	33	Whole blood	1 ml	3M2	2h
GSM632474	MYD88 P4_R6	F	MYD88-/- patient	AR MyD88 R6	Turkish	White	5	Whole blood	1 ml	R6	2h
GSM632475	control 9_CpG-D19	M	healthy control	Control CpG D19	France	White	31	Whole blood	1 ml	CpG-D19	2h
GSM632476	MYD88 P4_PMA/Iono	F	MYD88-/- patient	AR MyD88 PMA Iono	Turkish	White	5	Whole blood	1 ml	PMA/Iono	2h
GSM632477	control 9_PMA/Iono	M	healthy control	Control PMA Iono	France	White	31	Whole blood	1 ml	PMA/Iono	2h
GSM632478	MYD88 P3_IL18	F	MYD88-/- patient	AR MyD88 IL18	Traveller (Gypsies)	White	2	Whole blood	1 ml	IL18	2h
GSM632479	MYD88 P4__3M2	M	MYD88-/- patient	AR MyD88 3M2	Turkish	White	5	Whole blood	1 ml	3M2	2h
GSM632480	MYD88 P3_CpG C	F	MYD88-/- patient	AR MyD88 CpG C	Traveller (Gypsies)	White	2	Whole blood	1 ml	CpG C	2h
GSM632481	control1_v1_PAM3	M	healthy control	Control PAM3	France	White	28	Whole blood	1 ml	PAM3	2h
GSM632482	control1_v1_IL-1b	M	healthy control	Control IL1b	France	White	28	Whole blood	1 ml	IL-1b	2h
GSM632483	control4_v1_No stimulation	M	healthy control	Control No stimulation	France	White	35	Whole blood	1 ml	No stimulation	2h
GSM632484	control4_v1_3M13	M	healthy control	Control 3M13	France	White	35	Whole blood	1 ml	3M13	2h
GSM632485	control4_v1_PMA/Iono	M	healthy control	Control PMA Iono	France	White	35	Whole blood	1 ml	PMA/Iono	2h
GSM632486	MYD88 P2_CpG C	M	MYD88-/- patient	AR MyD88 CpG C	Portugal	White	11	Whole blood	1 ml	CpG C	2h
GSM632487	control3_v1_R848	F	healthy control	Control R848	France	White	34	Whole blood	1 ml	R848	2h
GSM632488	control1_v1_IL33	M	healthy control	Control IL33	France	White	28	Whole blood	1 ml	IL33	2h
GSM632489	control1_v1_IL18	M	healthy control	Control IL18	France	White	28	Whole blood	1 ml	IL18	2h
GSM632490	MYD88 P1_3M13	F	MYD88-/- patient	AR MyD88 3M13	Portugal	White	18	Whole blood	1 ml	3M13	2h
GSM632491	IRAK4 P1_poly(I:C)	M	IRAK4-/- patient	AR IRAK4 poly IC	Hungary	White	12	Whole blood	1 ml	poly(I:C)	2h
GSM632492	MYD88 P1_IL18	F	MYD88-/- patient	AR MyD88 IL18	Portugal	White	18	Whole blood	1 ml	IL18	2h
GSM632493	MYD88 P2_R848	M	MYD88-/- patient	AR MyD88 R848	Portugal	White	11	Whole blood	1 ml	R848	2h
GSM632494	MYD88 P1_TNFa	F	MYD88-/- patient	AR MyD88 TNFa	Portugal	White	18	Whole blood	1 ml	TNFa	2h
GSM632495	IRAK4 P2_Flagellin	M	IRAK4-/- patient	AR IRAK4 Flagellin	Spain	White	12	Whole blood	1 ml	Flagellin	2h
GSM632496	control4_v1__3M2	M	healthy control	Control 3M2	France	White	35	Whole blood	1 ml	3M2	2h
GSM632497	control3_v1_TNFa	F	healthy control	Control TNFa	France	White	34	Whole blood	1 ml	TNFa	2h
GSM632498	control1_v1_CpG C	M	healthy control	Control CpG C	France	White	28	Whole blood	1 ml	CpG C	2h
GSM632499	MYD88 P2_IL-1b	M	MYD88-/- patient	AR MyD88 IL1b	Portugal	White	11	Whole blood	1 ml	IL-1b	2h
GSM632500	control2_v1_Flagellin	F	healthy control	Control Flagellin	France	White	30	Whole blood	1 ml	Flagellin	2h
GSM632501	IRAK4 P2_TNFa	M	IRAK4-/- patient	AR IRAK4 TNFa	Spain	White	12	Whole blood	1 ml	TNFa	2h
GSM632502	IRAK4 P2_IL33	M	IRAK4-/- patient	AR IRAK4 IL33	Spain	White	12	Whole blood	1 ml	IL33	2h
GSM632503	MYD88 P2_CpG-D19	M	MYD88-/- patient	AR MyD88 CpG D19	Portugal	White	11	Whole blood	1 ml	CpG-D19	2h
GSM632504	MYD88 P1_CpG-D19	F	MYD88-/- patient	AR MyD88 CpG D19	Portugal	White	18	Whole blood	1 ml	CpG-D19	2h
GSM632505	MYD88 P1__3M2	F	MYD88-/- patient	AR MyD88 3M2	Portugal	White	18	Whole blood	1 ml	3M2	2h
GSM632506	IRAK4 P1_TNFa	M	IRAK4-/- patient	AR IRAK4 TNFa	Hungary	White	12	Whole blood	1 ml	TNFa	2h
GSM632507	control3_v1_CpG-D19	F	healthy control	Control CpG D19	France	White	34	Whole blood	1 ml	CpG-D19	2h
GSM632508	control1_v1_No stimulation	M	healthy control	Control No stimulation	France	White	28	Whole blood	1 ml	No stimulation	2h
GSM632509	control1_v1_PMA/Iono	M	healthy control	Control PMA Iono	France	White	28	Whole blood	1 ml	PMA/Iono	2h
GSM632510	IRAK4 P2_IL-1b	M	IRAK4-/- patient	AR IRAK4 IL1b	Spain	White	12	Whole blood	1 ml	IL-1b	2h
GSM632511	control3_v1__3M2	F	healthy control	Control 3M2	France	White	34	Whole blood	1 ml	3M2	2h
GSM632512	control2_v1_LPS	F	healthy control	Control LPS	France	White	30	Whole blood	1 ml	LPS	2h
GSM632513	MYD88 P2__3M2	M	MYD88-/- patient	AR MyD88 3M2	Portugal	White	11	Whole blood	1 ml	3M2	2h
GSM632514	MYD88 P2_3M13	M	MYD88-/- patient	AR MyD88 3M13	Portugal	White	11	Whole blood	1 ml	3M13	2h
GSM632515	MYD88 P2_PMA/Iono	M	MYD88-/- patient	AR MyD88 PMA Iono	Portugal	White	11	Whole blood	1 ml	PMA/Iono	2h
GSM632516	control1_v1_R848	M	healthy control	Control R848	France	White	28	Whole blood	1 ml	R848	2h
GSM632517	IRAK4 P1_IL-1b	M	IRAK4-/- patient	AR IRAK4 IL1b	Hungary	White	12	Whole blood	1 ml	IL-1b	2h
GSM632518	MYD88 P1_IL33	F	MYD88-/- patient	AR MyD88 IL33	Portugal	White	18	Whole blood	1 ml	IL33	2h
GSM632519	IRAK4 P1_PAM3	M	IRAK4-/- patient	AR IRAK4 PAM3	Hungary	White	12	Whole blood	1 ml	PAM3	2h
GSM632520	IRAK4 P2__3M2	M	IRAK4-/- patient	AR IRAK4 3M2	Spain	White	12	Whole blood	1 ml	3M2	2h
GSM632521	IRAK4 P2_3M13	M	IRAK4-/- patient	AR IRAK4 3M13	Spain	White	12	Whole blood	1 ml	3M13	2h
GSM632522	IRAK4 P2_PAM2	M	IRAK4-/- patient	AR IRAK4 PAM2	Spain	White	12	Whole blood	1 ml	PAM2	2h
GSM632523	IRAK4 P2_No stimulation	M	IRAK4-/- patient	AR IRAK4 No stimulation	Spain	White	12	Whole blood	1 ml	No stimulation	2h
GSM632524	IRAK4 P1_3M13	M	IRAK4-/- patient	AR IRAK4 3M13	Hungary	White	12	Whole blood	1 ml	3M13	2h
GSM632525	control2_v1_IL33	F	healthy control	Control IL33	France	White	30	Whole blood	1 ml	IL33	2h
GSM632526	control4_v1_Flagellin	M	healthy control	Control Flagellin	France	White	35	Whole blood	1 ml	Flagellin	2h
GSM632527	control1_v1_CpG-D19	M	healthy control	Control CpG D19	France	White	28	Whole blood	1 ml	CpG-D19	2h
GSM632528	control3_v1_IL18	F	healthy control	Control IL18	France	White	34	Whole blood	1 ml	IL18	2h
GSM632529	MYD88 P2_LPS	M	MYD88-/- patient	AR MyD88 LPS	Portugal	White	11	Whole blood	1 ml	LPS	2h
GSM632530	MYD88 P2_PAM3	M	MYD88-/- patient	AR MyD88 PAM3	Portugal	White	11	Whole blood	1 ml	PAM3	2h
GSM632531	control2_v1_PMA/Iono	F	healthy control	Control PMA Iono	France	White	30	Whole blood	1 ml	PMA/Iono	2h
GSM632532	control3_v1_CpG C	F	healthy control	Control CpG C	France	White	34	Whole blood	1 ml	CpG C	2h
GSM632533	control2_v1_No stimulation	F	healthy control	Control No stimulation	France	White	30	Whole blood	1 ml	No stimulation	2h
GSM632534	control2_v1_TNFa	F	healthy control	Control TNFa	France	White	30	Whole blood	1 ml	TNFa	2h
GSM632535	control1_v1_Flagellin	M	healthy control	Control Flagellin	France	White	28	Whole blood	1 ml	Flagellin	2h
GSM632536	control2_v1_CpG C	F	healthy control	Control CpG C	France	White	30	Whole blood	1 ml	CpG C	2h
GSM632537	IRAK4 P1_CpG C	M	IRAK4-/- patient	AR IRAK4 CpG C	Hungary	White	12	Whole blood	1 ml	CpG C	2h
GSM632538	control2_v1_poly(I:C)	F	healthy control	Control poly IC	France	White	30	Whole blood	1 ml	poly(I:C)	2h
GSM632539	control1_v1_TNFa	M	healthy control	Control TNFa	France	White	28	Whole blood	1 ml	TNFa	2h
GSM632540	IRAK4 P2_poly(I:C)	M	IRAK4-/- patient	AR IRAK4 poly IC	Spain	White	12	Whole blood	1 ml	poly(I:C)	2h
GSM632541	MYD88 P2_PAM2	M	MYD88-/- patient	AR MyD88 PAM2	Portugal	White	11	Whole blood	1 ml	PAM2	2h
GSM632542	IRAK4 P2_IL18	M	IRAK4-/- patient	AR IRAK4 IL18	Spain	White	12	Whole blood	1 ml	IL18	2h
GSM632543	IRAK4 P1_IL18	M	IRAK4-/- patient	AR IRAK4 IL18	Hungary	White	12	Whole blood	1 ml	IL18	2h
GSM632544	IRAK4 P2_CpG-D19	M	IRAK4-/- patient	AR IRAK4 CpG D19	Spain	White	12	Whole blood	1 ml	CpG-D19	2h
GSM632545	control4_v1_IL33	M	healthy control	Control IL33	France	White	35	Whole blood	1 ml	IL33	2h
GSM632546	IRAK4 P2_PAM3	M	IRAK4-/- patient	AR IRAK4 PAM3	Spain	White	12	Whole blood	1 ml	PAM3	2h
GSM632547	IRAK4 P2_LPS	M	IRAK4-/- patient	AR IRAK4 LPS	Spain	White	12	Whole blood	1 ml	LPS	2h
GSM632548	IRAK4 P2_CpG C	M	IRAK4-/- patient	AR IRAK4 CpG C	Spain	White	12	Whole blood	1 ml	CpG C	2h
GSM632549	control4_v1_CpG-D19	M	healthy control	Control CpG D19	France	White	35	Whole blood	1 ml	CpG-D19	2h
GSM632550	IRAK4 P1_PMA/Iono	M	IRAK4-/- patient	AR IRAK4 PMA Iono	Hungary	White	12	Whole blood	1 ml	PMA/Iono	2h
GSM632551	IRAK4 P1_No stimulation	M	IRAK4-/- patient	AR IRAK4 No stimulation	Hungary	White	12	Whole blood	1 ml	No stimulation	2h
GSM632552	control1_v1_3M13	F	healthy control	Control 3M13	France	White	28	Whole blood	1 ml	3M13	2h
GSM632553	control4_v1_TNFa	M	healthy control	Control TNFa	France	White	35	Whole blood	1 ml	TNFa	2h
GSM632554	IRAK4 P1_LPS	M	IRAK4-/- patient	AR IRAK4 LPS	Hungary	White	12	Whole blood	1 ml	LPS	2h
GSM632555	control4_v1_IL-1b	M	healthy control	Control IL1b	France	White	35	Whole blood	1 ml	IL-1b	2h
GSM632556	control2_v1_R848	F	healthy control	Control R848	France	White	30	Whole blood	1 ml	R848	2h
GSM632557	MYD88 P1_No stimulation	F	MYD88-/- patient	AR MyD88 No stimulation	Portugal	White	18	Whole blood	1 ml	No stimulation	2h
GSM632558	MYD88 P1_R848	F	MYD88-/- patient	AR MyD88 R848	Portugal	White	18	Whole blood	1 ml	R848	2h
GSM632559	control4_v1_IL18	M	healthy control	Control IL18	France	White	35	Whole blood	1 ml	IL18	2h
GSM632560	control4_v1_PAM3	M	healthy control	Control PAM3	France	White	35	Whole blood	1 ml	PAM3	2h
GSM632561	IRAK4 P1_R848	M	IRAK4-/- patient	AR IRAK4 R848	Hungary	White	12	Whole blood	1 ml	R848	2h
GSM632562	IRAK4 P1__3M2	M	IRAK4-/- patient	AR IRAK4 3M2	Hungary	White	12	Whole blood	1 ml	3M2	2h
GSM632563	control3_v1_IL-1b	F	healthy control	Control IL1b	France	White	34	Whole blood	1 ml	IL-1b	2h
GSM632564	control2_v1_IL18	F	healthy control	Control IL18	France	White	30	Whole blood	1 ml	IL18	2h
GSM632565	MYD88 P2_poly(I:C)	M	MYD88-/- patient	AR MyD88 poly IC	Portugal	White	11	Whole blood	1 ml	poly(I:C)	2h
GSM632566	MYD88 P2_Flagellin	M	MYD88-/- patient	AR MyD88 Flagellin	Portugal	White	11	Whole blood	1 ml	Flagellin	2h
GSM632567	MYD88 P1_CpG C	F	MYD88-/- patient	AR MyD88 CpG C	Portugal	White	18	Whole blood	1 ml	CpG C	2h
GSM632568	MYD88 P1_PMA/Iono	F	MYD88-/- patient	AR MyD88 PMA Iono	Portugal	White	18	Whole blood	1 ml	PMA/Iono	2h
GSM632569	control3_v1_LPS	F	healthy control	Control LPS	France	White	34	Whole blood	1 ml	LPS	2h
GSM632570	control4_v1_R848	M	healthy control	Control R848	France	White	35	Whole blood	1 ml	R848	2h
GSM632571	MYD88 P1_IL-1b	F	MYD88-/- patient	AR MyD88 IL1b	Portugal	White	18	Whole blood	1 ml	IL-1b	2h
GSM632572	IRAK4 P2_R848	M	IRAK4-/- patient	AR IRAK4 R848	Spain	White	12	Whole blood	1 ml	R848	2h
GSM632573	IRAK4 P1_IL33	M	IRAK4-/- patient	AR IRAK4 IL33	Hungary	White	12	Whole blood	1 ml	IL33	2h
GSM632574	control2_v1_IL-1b	F	healthy control	Control IL1b	France	White	30	Whole blood	1 ml	IL-1b	2h
GSM632575	IRAK4 P1_CpG-D19	M	IRAK4-/- patient	AR IRAK4 CpG D19	Hungary	White	12	Whole blood	1 ml	CpG-D19	2h
GSM632576	control2_v1__3M2	F	healthy control	Control 3M2	France	White	30	Whole blood	1 ml	3M2	2h
GSM632577	MYD88 P1_PAM3	F	MYD88-/- patient	AR MyD88 PAM3	Portugal	White	18	Whole blood	1 ml	PAM3	2h
GSM632578	control3_v1_poly(I:C)	F	healthy control	Control poly IC	France	White	34	Whole blood	1 ml	poly(I:C)	2h
GSM632579	MYD88 P1_LPS	F	MYD88-/- patient	AR MyD88 LPS	Portugal	White	18	Whole blood	1 ml	LPS	2h
GSM632580	control3_v1_PAM3	F	healthy control	Control PAM3	France	White	34	Whole blood	1 ml	PAM3	2h
GSM632581	MYD88 P1_Flagellin	F	MYD88-/- patient	AR MyD88 Flagellin	Portugal	White	18	Whole blood	1 ml	Flagellin	2h
GSM632582	control1_v1_poly(I:C)	M	healthy control	Control poly IC	France	White	28	Whole blood	1 ml	poly(I:C)	2h
GSM632583	control3_v1_PAM2	F	healthy control	Control PAM2	France	White	34	Whole blood	1 ml	PAM2	2h
GSM632584	control4_v1_PAM2	M	healthy control	Control PAM2	France	White	35	Whole blood	1 ml	PAM2	2h
GSM632585	control3_v1_3M13	F	healthy control	Control 3M13	France	White	34	Whole blood	1 ml	3M13	2h
GSM632586	control1_v1_LPS	M	healthy control	Control LPS	France	White	28	Whole blood	1 ml	LPS	2h
GSM632587	control3_v1_Flagellin	F	healthy control	Control Flagellin	France	White	34	Whole blood	1 ml	Flagellin	2h
GSM632588	MYD88 P2_IL18	M	MYD88-/- patient	AR MyD88 IL18	Portugal	White	11	Whole blood	1 ml	IL18	2h
GSM632589	MYD88 P1_PAM2	F	MYD88-/- patient	AR MyD88 PAM2	Portugal	White	18	Whole blood	1 ml	PAM2	2h
GSM632590	control2_v1_CpG-D19	F	healthy control	Control CpG D19	France	White	30	Whole blood	1 ml	CpG-D19	2h
GSM632591	control1_v1_PAM2	M	healthy control	Control PAM2	France	White	28	Whole blood	1 ml	PAM2	2h
GSM632592	MYD88 P2_IL33	M	MYD88-/- patient	AR MyD88 IL33	Portugal	White	11	Whole blood	1 ml	IL33	2h
GSM632593	IRAK4 P1_PAM2	M	IRAK4-/- patient	AR IRAK4 PAM2	Hungary	White	12	Whole blood	1 ml	PAM2	2h
GSM632594	control1_v1__3M2	M	healthy control	Control 3M2	France	White	28	Whole blood	1 ml	3M2	2h
GSM632595	control2_v1_PAM2	F	healthy control	Control PAM2	France	White	30	Whole blood	1 ml	PAM2	2h
GSM632596	control4_v1_LPS	M	healthy control	Control LPS	France	White	35	Whole blood	1 ml	LPS	2h
GSM632597	control3_v1_PMA/Iono	F	healthy control	Control PMA Iono	France	White	34	Whole blood	1 ml	PMA/Iono	2h
GSM632598	IRAK4 P1_Flagellin	M	IRAK4-/- patient	AR IRAK4 Flagellin	Hungary	White	12	Whole blood	1 ml	Flagellin	2h
GSM632599	control2_v1_PAM3	F	healthy control	Control PAM3	France	White	30	Whole blood	1 ml	PAM3	2h
GSM632600	control3_v1_IL33	F	healthy control	Control IL33	France	White	34	Whole blood	1 ml	IL33	2h
GSM632601	MYD88 P1_poly(I:C)	F	MYD88-/- patient	AR MyD88 poly IC	Portugal	White	28	Whole blood	1 ml	poly(I:C)	2h
GSM632602	control4_v1_poly(I:C)	M	healthy control	Control poly IC	France	White	35	Whole blood	1 ml	poly(I:C)	2h
GSM632603	control4_v1_CpG C	M	healthy control	Control CpG C	France	White	35	Whole blood	1 ml	CpG C	2h
GSM632604	MYD88 P2_No stimulation	M	MYD88-/- patient	AR MyD88 No stimulation	Portugal	White	11	Whole blood	1 ml	No stimulation	2h
GSM632605	MYD88 P2_TNFa	M	MYD88-/- patient	AR MyD88 TNFa	Portugal	White	11	Whole blood	1 ml	TNFa	2h
GSM632606	control3_v1_No stimulation	F	healthy control	Control No stimulation	France	White	34	Whole blood	1 ml	No stimulation	2h

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